Gonorrhoea Research Today is a free monthly online journal that collates and summarizes the latest research about Gonorrhoea, including details on symptoms, causes, stds, treatment, cures.

Core groups, antimicrobial resistance and rebound in gonorrhoea in North America.

Chan CH, McCabe CJ, Fisman DN

division of Epidemiology, Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, 155 College Street, Room 678, Toronto, Ontario, Canada M5T 3M7.

Published 14 March 2012 in Sex Transm Infect, 88(3): 200-4.
Full-text of this article is available online (may require subscription).

Articles on Gonorrhoea published 12 March 2012:

Fur-mediated activation of gene transcription in the human pathogen Neisseria gonorrhoeae.   J Bacteriol, 194(7): 1730-42.

It is well established that the ferric uptake regulatory protein (Fur) functions as a transcriptional repressor in diverse microorganisms. Recent studies demonstrated that Fur also functions as a transcriptional activator. In this study we defined Fur-mediated activation of gene transcription in the sexually transmitted disease pathogen Neisseria gonorrhoeae. Analysis of 37 genes which were previously determined to be iron induced and which contained putative Fur boxes revealed that only 30 of ... [Abstract] [Full-text]

Articles on Gonorrhoea published 6 March 2012:

Changes in fluoroquinolone use for gonorrhea following publication of revised treatment guidelines.   Am J Public Health, 102(1): 148-55.

[Abstract] [Full-text]

Articles on Gonorrhoea published 23 February 2012:

Neisseria gonorrhoeae with high-level resistance to azithromycin: case report of the first isolate identified in the United States.   Clin Infect Dis, 54(6): 841-3.

We report on the first Neisseria gonorrhoeae isolate in the United States identified with high-level resistance to azithromycin. This report discusses the epidemiologic case investigation, the molecular studies of resistance-associated mutations and N. gonorrhoeae multiantigen sequence typing, and challenges posed by emerging gonococcal antimicrobial resistance. [Abstract] [Full-text]

Articles on Gonorrhoea published 22 February 2012:

Disseminated gonococcal infection in women.   Obstet Gynecol, 119(3): 597-602.

[Abstract] [Full-text]

Articles on Gonorrhoea published 16 February 2012:

Antimicrobial susceptibility testing, auxotyping, and serotyping of Neisseria gonorrhoeae strains isolated in India.   Sex Transm Dis, 39(3): 188-90.

Sixty-four Neisseria gonorrhoeae strains isolated from patients attending sexually transmitted disease clinics at Pune and Delhi between January 2007 and June 2008, were subjected to antimicrobial susceptibility testing, auxotyping, and serotyping. We observed 6 antibiotic resistance patterns, 6 auxotypes, 3 serogroups, and 17 serovars. The combination of auxotyping and serotyping is a potential useful method for typing N. gonorrhoeae as a result of high discriminatory index, rapidity, ease, ... [Abstract] [Full-text]

Articles on Gonorrhoea published 10 February 2012:

Update on antimicrobial susceptibility and genotype of Neisseria gonorrhoeae isolated in Italy.   Diagn Microbiol Infect Dis, 72(3): 288-90.

Antimicrobial susceptibilities and genotypes of Neisseria gonorrhoeae collected in 2006-2010 from 6 medical centers located in Italy were compared with those from a previous survey conducted in 2003-2005. Resistance to ciprofloxacin increased from 34.2% to 62% whereas penicillin resistance declined from 25.5% to 14%. Important change in antimicrobial resistance rates and a high genetic variability among N. gonorrhoeae from Italy were observed. [Abstract] [Full-text]

Articles on Gonorrhoea published 8 February 2012:

The role of catalase in gonococcal resistance to peroxynitrite.   Microbiology, 158: 560-70.

We have reported that Neisseria gonorrhoeae is extremely resistant to reactive nitrogen species (RNS) including peroxynitrite (PN). Recent literature suggests that catalase can provide protection against commercial preparations of PN. Though wild-type gonococci were shown to be highly resistant to 2 mM PN, Neisseria meningitidis and a gonococcal katA mutant were both shown to be extremely sensitive to 2 mM PN. Analysis of translational fusions to lacZ of the catalase promoters from N. ... [Abstract] [Full-text]

Articles on Gonorrhoea published 3 February 2012:

Sexually transmitted infections in newly arrived refugees: is routine screening for Neisseria gonorrheae and Chlamydia trachomatis infection indicated?   Am J Trop Med Hyg, 86(2): 292-5.

More than 340 million cases of bacterial and protozoal sexually transmitted infections (STIs) occur annually. Approximately 70,000 refugees arrive in the United States on a yearly basis. Refugees are a particularly disenfranchised and vulnerable population. The prevalence of Chlamydia and gonorrhea in refugee populations has not been described, and the utility of routine screening is unknown. We performed a descriptive evaluation of 25,779 refugees who completed a screening medical examination ... [Abstract] [Full-text]

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